Firefighters were called to the 2700 block of Dover Street around 4:20 a.m., a department spokesperson said.
They arrived to find heavy fire on the topside of a two-story home, officials said. Firefighters brought the flames under control by 5 a.m.
No other injuries were reported and PFD did not identify the victim by name.
The Fire Marshal's Office is investigating the cause of the blaze, they added.
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